The purpose of this clinical trial is to compare the pharmacokinetic characteristics of GL2907 XL 20mg tablet and Oxycontin CR 10mg tablet.
GL2907 XL 20mg tablet is controlled released formulation which is made by GL Pharm Tech.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
24
once a day
twice a day
AJOU University Hospital
Suwon, Gyeonggido, South Korea
Cmax,ss
Pharmacokinetic of Oxycodone
Time frame: 48h
AUCτ
Pharmacokinetic of Oxycodone
Time frame: 24h
Tmax
Pharmacokinetic of Oxycodone
Time frame: 48h
t1/2
Pharmacokinetic of Oxycodone
Time frame: 48h
Vz/f
Pharmacokinetic of Oxycodone
Time frame: 48h
CL/F
Pharmacokinetic of Oxycodone
Time frame: 48h
Cmin,ss
Pharmacokinetic of Oxycodone
Time frame: 48h
Cave,ss
Pharmacokinetic of Oxycodone
Time frame: 48h
degree og fluctuation
Pharmacokinetic of Oxycodone (Cmax,ss-Cmin,ss)/Cave,ss
Time frame: 48h
swing
Pharmacokinetic of Oxycodone (Cmax,ss-Cmin,ss)/Cmin,ss
Time frame: 48h
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R
Pharmacokinetic of Oxycodone Accumulation index
Time frame: 48h