ET-blockade and Exercise Induced Blood Flow in T2DM

Radboud University Medical Center22 enrolled

Overview

The purpose of this study is to establish the effect of ET blockade on the acute exercise induced blood flow and endothelial function in subjects with T2DM. We hypothesize that combining ET - blockade with exercise training leads to an acute increase of exercise induced blood flow when compared with exercise alone. We expect that this will lead to an optimization of vascular training effect in T2DM.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Type 2 Diabetes Mellitus

Interventions

BosentanDRUG

PlaceboDRUG

Eligibility

Sex: MALEMin age: 40 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Type 2 Diabetes Mellitus (\>2 years since diagnosis) OR controls Exclusion Criteria: * \<40 years of age * \>65 years of age * smoking * cardiovascular disease * diabetes related manifest vascular complications * Type 1 Diabetes Mellitus * use of Glibenclamide * use of HIV drugs * use of calcineurin inhibitors * use of drugs that interfere with CYP3A4 and CYP2C19

Locations (1)

Radboud University Nijmegen Medical Centre

Nijmegen, Gelderland, Netherlands

Outcomes

Primary Outcomes

exercise induced blood flow

Time frame: 2 hours

Secondary Outcomes

exercise induced Flow Mediated Dilation

Time frame: 2 hours

Data from ClinicalTrials.gov

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