Rapid Versus Slow Ingestion of Mixed Meal: Influence on Islet and Incretin Hormone Secretion in Healthy Volunteers

Lund University24 enrolled

Overview

To test the influence of rapid versus slow ingestion of a mixed meal on insulin and incretin hormone secretion in healthy volunteers

A mixed meal (524 kcal) is ingested rapidly (within 5 min) or slowly (10-15 min) and changes in insulin, glucagon, GIP and GLP-1 levels are followed for subsequent 300 min

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy Volunteers Recruited From the General Population

Interventions

Mixed mealOTHER

Ingestion of mixed meal

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy subjects Exclusion Criteria: * Diabetes Liver disease Kidney disease Thyroid disease

Locations (1)

Department of Clinical Sciences, Lund University

Lund, Sweden

Outcomes

Primary Outcomes

Area under the curve for insulin

Time frame: 300 min

Secondary Outcomes

Area under the curve for glucose-dependent insuinotropic polypeptide

Time frame: 300 min

Area under the curve for glucagon-like peptide-1

Time frame: 300 min

Data from ClinicalTrials.gov

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