The purpose of this study is to evaluate the efficacy of a probiotic strain in improving the quality of life in adult subjects suffering from perennial allergic rhinit.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
64
maltodextrin
Metabolic Unit, Nestlé Research Centre
Lausanne, Switzerland
Quality of life, measured by a validated mini rhinoconjunctivitis quality of life questionnaire (MiniRQLQ)
Compared over 8 weeks between the two treatment groups
Time frame: 8 weeks
Level of pro-inflammatory cytokines in ex-vivo stimulated whole blood cells
Time frame: Measured 3 times: at the start of product intake, after 4 weeks and after 8 weeks
Basophil activation in ex-vivo stimulated whole blood cells
Time frame: Measured 3 times: at the start of product intake, after 4 weeks and after 8 weeks
Total Nasal Symptom Score (TNSS), Total Ocular Symptom Score (TOSS), Medication score
Time frame: Measured weekly for the 8 weeks of product intake
Level of Specific Immunoglobulin E
Time frame: Measured 2 times: at the start of product intake and after 8 weeks
Frequency of adverse events
Time frame: during the 8 weeks of product intake
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