Remote Observed Dosing to Increase Suboxone Compliance

Inclusion Criteria: * Voluntarily provide written informed consent prior to the conduct of any study-related procedure * Male or female, 18 to 65 years of age, * Meet DSM-IV criteria for current opioid dependence * Females of childbearing potential and fertile males must use a reliable means of contraception * Owns a smartphone with forward facing camera that allows for use of Skype Exclusion Criteria: * University of Pennsylvania student, employee, or affiliate * Current diagnosis of AIDS * Presence of AST and/or ALT equal to or 3X upper limit of normal * Total bilirubin and/or creatinine equal to or 1.5X upper limit or normal * Current diagnosis of chronic pain requiring opioids * Pregnant or lactating females * Previous hypersensitivity or allergy to buprenorphine or EVA-containing substances * Current use of agents metabolized through CYP 3A4 such as azole antifungals (e.g. ketoconazole), macrolide antibiotics (e.g. erythromycin), and protease inhibitors (e.g. ritonavir, indinavir, saquinavir) * Meet DSM-IV criteria for current dependence on any psychoactive substances other than opioids or nicotine (e.g. alcohol, sedatives) * Current use of benzodiazepines other than physician prescribed * Significant medical or psychiatric symptoms or dementia which in the opinion of the investigators would preclude compliance with the protocol, adequate cooperation in the study, or obtaining informed consent * Concurrent medical conditions (such as severe respiratory insufficiency) that may prevent the patient from safely participating in the study; and/or any pending legal action that could prohibit participation and/or compliance in study procedures * Participated in a clinical study within the previous 8 weeks