Osteosarcoma and Ewing Sarcoma Treatment Response Assessment With Functional MRI Imaging in Children and Young Adults

Universitaire Ziekenhuizen KU Leuven25 enrolled

Overview

The purpose of the study was to investigate whether functional MRI imaging (diffusion weighted imaging) is useful for monitoring the therapeutic response of bone sarcomas in children and young adults. All patients will be scanned before, during and after chemotherapy. The findings on MRI will be correlated with histological finding after surgery. Second purpose : to define apparent diffusion coefficient value of the bone sarcoma. Third purpose : to try define prognostic factors, to investigate if there is a correlation between early treatment response and outcome.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Ewing Sarcoma Osteosarcoma

Interventions

MRIOTHER

MRI exam will be performed in all patients included in the study. The patients will be treated by chemotherapy, defined in the EURO-EWING or EURAMOS protocol. The MR findings will not have any impact on the treatment.

Medical Language ↔ Plain English

Inclusion Criteria: * Ewing or Osteosarcoma, proven by biopsy and histopathology * all patients are treated by chemotherapy defined by EURAMOS and EURO-EWING protocol Exclusion Criteria: * Patients under the age of 6 years old * patients with contra-indication for MR exam (pace-maker...) * Patients with renal insufficiency * Claustrophobia

Outcomes

Primary Outcomes

tumor necrosis - therapy response

correlation of MRI findings with clinical findings during chemotherapy correlation of diffusion weighted MRI and histopathology results after surgical resection. Calculation of apparent diffusion coefficient : is it a valuable parameter?

Time frame: 6 months

Secondary Outcomes

Prognosis and outcome

Is there a correlation between early treatment response and outcome? Is diffusion weighted MRI able to predict outcome of the patient (prognostic factor)?

Time frame: 2 years