S4 :Trial Of Fully Closed-Loop Ventilation In ICU.

Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer60 enrolled

Overview

Preliminary study to compare IntelliVent-ASV to conventional modes used from intubation to extubation or death in ICU patients requiring mechanical ventilation measuring duration of mechanical ventilation in order to design a multicenter large trial.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Intensive Care Patients Invasively Ventilated

Interventions

INTELLIVENT ASV FULLY CLOSED-LOOP VENTILATIONDEVICE

Conventionals ModesDEVICE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion criteria: \- Unselected ICU patients invasively ventilated for less than 24 hours, with an expected duration of MV longer than 48 hours. Exclusion criteria: * broncho-pleural fistula * dyshemoglobulinémia * moribund patient * do-not-resuscitate order * chronic respiratory failure requiring long term ventilation, * patient ventilated more than 24 hours before admission, * pregnancy, * age below 18 years, * protected patients, * patient already participating in the study, * Cheynes-Stockes breathing. * Included patients with a treatment withdrawal decision within 24 hours after inclusion will be excluded, * patients transferred to another ICU, * patients needing ECMO, patients randomized to IntelliVent having less than 20% of time in IntelliVent-ASV.

Locations (2)

Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

Toulon, Paca, France

Anestesia e Rianimazione 2, Fondazione IRCCS Policlinico S. Matteo

Pavia, Lombardy, Italy