Vitamin D Supplementation to Obese Chinese Males

Shenzhen Center for Chronic Disease Control43 enrolled

Overview

Hypothesis: Oral Supplementation of Vitamin D can Reduce Hypersecretion of Parathyroid Hormone and Insulin Resistance in Obese Chinese Males. Protocol: Weekly oral supplementation of 50,000 IU vitamin D (cholecalciferol) or eight weeks to the obese males compared with the normal-weight males. Index measures were conducted at baseline and endpoint.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Obesity Insulin Resistance

Interventions

Oral supplementation of vitamin DDIETARY_SUPPLEMENT

Weekly oral supplementation of 50,000 IU vitamin D (cholecalciferol) for eight weeks to the obese males compared with the normal-weight males. The chemical form of vitamin D is cholecalciferol capsuled as fine powder.

Eligibility

Sex: MALEMin age: 23 YearsMax age: 66 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * body mass index (BMI) ≥ 28kg/m2 or 18.5 ≤ BMI \< 24 (kg/m2) * non vegetarian Han Chinese and did not smoke, drink, nor take vitamin D supplements for \> 2 y * fasting serum glucose \< 7.0 mmol/L * serum glucose of 2 hr after 75 g oral glucose loading \< 11.1 mmol/L * normal functioning of liver and kidney evaluated by alkaline phosphatase, aspartate aminotransferase, creatinine, and uric acid Exclusion Criteria: * not match the above inclusion criteria * diagnosed as having any organic diseases were excluded

Locations (1)

Shenzhen Center for Chronic Disease Control

Shenzhen, Guangdong, China

Outcomes

Primary Outcomes

Plasma 25-hydroxy Vitamin D (25(OH)D) Level (Nmol/L)

Time frame: Endpoint and baseline of the 8 weeks' trial

Data from ClinicalTrials.gov

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