Changes in Metabolic Status in Patients With Total Thyroidectomy

Tel-Aviv Sourasky Medical Center50 enrolled

Overview

This study objective is to evaluate the change in mitochondrial uncoupling protein 2 (UCP2) mRNA expression as function of thyroid activity (TSH, T3 and Free T4).

Blood will be drown before thyroidectomy, 2 weeks after the operation and 3-4 month after the operation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Thyroid Cancer

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who were diagnosed with thyroid carcinoma and are going to have total thyroidectomy. * Patients with unbalanced thyroid hormones. * Aged 18-65 years at the time of screening. * Provision of written informed consent. Exclusion Criteria: * Patients with Diabetes. * Patients with any other chronic inflammatory diseases. * Steroid treatment.

Locations (1)

Tel Aviv Sourasky Medical Center

Tel Aviv, Israel

RECRUITING

Outcomes

Primary Outcomes

Changes in UCP2 mRNA concentrations.

The difference between the result at two weeks and four months compare to base line.

Time frame: Base line (before opporation), 2 weeks after opporation and for after opporation.

Secondary Outcomes

Weight

Time frame: Approximately 4 months

Resting energy expenditure

Time frame: Approximatly 4 months

Central Contacts

Nachum Vaisman, M.D.

CONTACT

972-3-6974807 vaisman@tasmc.health.gov.il

Data from ClinicalTrials.gov

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