Intervention to Promote Changes of Healthy Lifestyle (Physical Activity and Nutrition) During Gestation

Université de Sherbrooke16 enrolled

Overview

The purpose of this study are: * Assess the impact of an intervention to the adoption of healthy lifestyles among pregnant women at high risk of gestational diabetes mellitus on: * weight gain in pregnancy * the levels of maternal and fetal adipokines and * glycemic control maternal and fetal. * Determine whether the adoption of healthy lifestyles in pregnancy is associated with epigenetic changes that influence the levels of adipokines and glucose regulation during pregnancy and in newborns.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Excessive Weight Gain During Pregnancy Gestational Diabetes

Interventions

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * be aged ≥ 18 years, * have a pre-pregnancy BMI ≥ 25 kg/m2, * be at risk of developing a gestational diabetes mellitus (a history of gestational diabetes mellitus or glucose 1 hour post-50g \> 7.1 mmol/L. Exclusion Criteria: * Pre-pregnancy diabetes detected in the first trimester (A1c \> 6.5%, fasting glucose \> 7.0 mmol/L, random blood glucose\> 11.1 mmol/L, glucose \> 10.3 mmol/L 1 hour post-50g) * twin pregnancy * taking medications that can affect blood sugar or weight, * practice ≥ 150 minutes of physical activity per week * against formal-indication for physical activity.

Outcomes

Primary Outcomes

Weight change during pregnancy

Time frame: Weeks 12, 24, 36 of gestation

Secondary Outcomes

Levels of maternal and fetal adipokines

Time frame: Weeks 12, 24 of gestation and at delivery (in cord blood)

Maternal and fetal glycemic control

Results of glucose tolerance test (50g and 75g)

Time frame: Weeks 12, 24 of gestation and at delivery

Determine whether the adoption of healthy lifestyle in pregnancy is associated with epigenetic changes that influence the levels of adipokines and glucose regulation during pregnancy and in newborns.

Time frame: Weeks 12, 24 of gestation and at delivery (cord blood)

Optimize the intervention before measuring its impact on the prevention of gestational diabetes mellitus on a larger scale.

Documentation will be collected about appreciation of the participants and attendance.

Time frame: throughout the study