This a prospective, non-controlled, open, multi-center study evaluating the reduction of bacteriuria after bladder irrigation with chlorhexidine in spinal cord injured patients with chronic bacteriuria practicing intermittent catheterisation (IC). Patients will be treated with chlorhexidine for bladder irrigation twice daily for a maximum of 7 days. The study hypothesis is that bladder irrigation with chlorhexidine is efficient for a short term reduction of bacteriuria in patients performing intermittent catheterization (IC).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
50
Bladder irrigation with chlorhexidine 0.2 mg/ml twice daily
Spinal Cord Injury Unit, Sahlgrenska University Hospital
Gothenburg, Sweden
Spinal Cord Injury Unit, Skåne University Hospital
Höör, Sweden
Spinal Cord Injury Unit, Linköping University Hospital
Linköping, Sweden
Neurocentrum, Neurorehab, Norrlands Universitetssjukhus
Umeå, Sweden
Proportion of patients with bacteriuria <10^3 CFU/ml
Bacteriuria will be followed by daily urinary cultures, 3 hours after morning irrigation. The proportion of patients with at least one sample \<10\^3 CFU/ml within the 7 day treatment period will be evaluated.
Time frame: 7 days
Time (number of days) to reduction of bacteriuria (<10^3 CFU/ml)
Bacteriuria will be followed by daily urinary cultures, 3 hours after morning irrigation. The number of days until reduction of bacteriuria (\<10\^3 CFU/ml) will be evaluated. Maximum treatment period is 7 days.
Time frame: 7 days
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