Influence of a Single Dose Dexamethasone on the Time Course of Neuromuscular Blockade of Rocuronium

Kreiskrankenhaus Dormagen108 enrolled

Overview

The aim of the present study is to compare the time course of a neuromuscular block in patients receiving dexamethasone 8 mg in order to reduce postoperative nausea or vomiting several hours before surgery with patients receiving the drug immediately before induction of anaesthesia and patients without a dexamethasone prophylaxis. The primary end point is the time from start of injection of rocuronium until recovery to a train of four ratio (TOF ratio) of 0.9.

Study Type

OBSERVATIONAL

Enrollment

108

Conditions

Neuromuscular Block, Dexamethasone Neuromuscular Block, Recovery

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients aged 18 to 65 years, * American Society of Anesthesiologists Physical Status I or II, * 50-90 kg body weight, * undergoing elective laparoscopic gynaecological surgery in general anaesthesia necessitating intraoperative neuromuscular blockade. Exclusion Criteria: * expected difficulties with endotracheal intubation (history of difficult intubation, * reduced opening of the mouth (\< 2cm), and Mallampati Score of 4), * increased risk of pulmonary aspiration (gastrooesophageal reflux, full stomach, intestinal obstruction), * known allergies to the drugs tested, * pregnancy, * neuromuscular disorders, * intake of drugs affecting neuromuscular blockade, such as furosemide, magnesium or cephalosporins, * hepatic-or renal insufficiency.

Locations (1)

Kreiskrankenhaus Dormagen

Dormagen, Germany

Outcomes

Primary Outcomes

the time from start of injection of rocuronium until recovery to a train of four ratio (TOF ratio) of 0.9.

Time frame: one hour

Data from ClinicalTrials.gov

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