Studies have shown that surgery causes some reactions in your body consistent with inflammation. When the inflammation is extensive, it may affect different parts of the body including the lungs. Corticosteroids are commonly used to treat inflammation and are different from performance enhancing steroids associated with athletics. The purpose of this study is to determine the influence of low dose steroids given 3 times in a 24 hour period on thrombotic markers (markers that are associated with increased risks of clotting, a possible complication of surgery), interleukin (IL)-6 cytokine release (part of the stress response seen with surgery), and urine desmosine levels (a marker of lung injury) in a randomized placebo controlled trial patients undergoing total hip replacement.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
40
Hospital for Special Surgery
New York, New York, United States
Serum Prothrombin Fragment 1 and 2 (PF 1.2)
Time frame: First 24 hours after surgery
Plasmin-a 2 Antiplasmin Complex (PAP)
Time frame: First 24 hours after surgery
Interleukin (IL)-6 Cytokine Release (Inflammatory Marker)
The time frame of the study for each patient covers the period between time of surgery and until discharge from the hospital.
Time frame: Participants will be followed from the time of surgery until discharge, expected average of 3-5 days
Desmosine Level (Marker of Lung Injury)
The time frame of the study for each patient covers the period between time of surgery and until discharge from the hospital.
Time frame: Participants will be followed from the time of surgery until discharge, expected average of 3-5 days
Pain at 3 Months Post-op
At 3 months postoperatively, patients were asked to rate their pain on a scale of 0-10, with 0 being no pain and 10 being worst pain.
Time frame: 3 months postoperatively
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