Polycystic ovary syndrome (PCOS) is characterized by enlarged ovaries, menstrual irregularity and hyperandrogenism and is the most common cause of oligoovulatory infertility. Insulin resistance with resulting hyperinsulinemia is also common among women with PCOS, along with increased risk for dyslipidemia, hypertension, diabetes and related cardiovascular consequences. Resveratrol is a natural polyphenol with anti-carcinogenic, anti-proliferative and pro-apoptotic properties, that has been shown to decrease proliferation and steroidogenesis in theca cells, emerging as a potential therapeutic agent in PCOS patients. However, little is known about its potential beneficial effect on oocyte quality as well as other reproductive outcomes, such as implantation an pregnancy rates. The present study evaluates effects of resveratrol on selected biochemical parameters and reproductive outcome among patients with PCOS who undergo in vitro fertilization (IVF).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
10
The patients will take 2 g of resveratrol per day for 40 days.
The patients will take placebo for 40 days.
Ivi Madrid
Madrid, Spain
Effect of resveratrol on oocyte quality
Time frame: 40 days
Effect of resveratrol on testosterone levels.
Time frame: 40 days
Effects of resveratrol on inflammatory markers
Time frame: 40 days
Effects of resveratrol on the fertilization rate.
Time frame: 40 days
Effects of resveratrol on the pregnancy rate.
Time frame: 40 days
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