Tricuspid Regurgitant Jet Velocity as an Independent Marker for Mortality in Sickle Cell Anemia

Namita Sood209 enrolled

Overview

The purpose of this study is to evaluate patients with pulmonary hypertension and sickle cell disease who have had multiple echocardiograms. Previous studies have shown that an elevated tricuspid jet (TR) regurgitant velocity on echo in this population is a predictor of mortality. This initial data only examined an isolated TR jet velocity. It was presumed that the mortality was related to pulmonary hypertension. It is the aim of this study to retrospectively evaluate patients who have had multiple echocardiograms and to determine if patients who had either a normalization of their TR jet velocity on a subsequent echo or had no evidence of pulmonary hypertension on right heart catheterization had a similar mortality rate to those with persistently elevated TR jet velocity.

Study Type

OBSERVATIONAL

Enrollment

209

Conditions

Sickle Cell Anemia Pulmonary Hypertension

Interventions

Data CollectionOTHER

Collection of data from existing medical records

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

To limit bias in this study all patients that with sickle cell anemia and pulmonary hypertension with the pre-specified data required will be included.

Locations (1)

The Ohio State University Medical Center

Columbus, Ohio, United States

Outcomes

Primary Outcomes

A retrospective review on patients who have had multiple echocardiograms to determine if patients with a normalization of TR Jet Velocity have changes in risk of death compared with those who do not have normalization of TR Jet Velocity.

Any subject's who meet criteria and have multiple echocardiograms may be included.

Time frame: Up to 20 years

Data from ClinicalTrials.gov

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