Safety, Pharmacokinetic, and Pharmacodynamic Study of NKTT120 in Adult Patients With Stable Sickle Cell Disease (SCD)

Inclusion Criteria: * Age 18 to 50 years * Subject has a confirmed diagnosis of HbSS or HbSβ0thal * Subject has stable SCD defined as not having acute VOC, ACS, or other major SCD associated event during the month prior to enrollment Exclusion Criteria: * Subject had an SCD-related VOC or ACS that required hospitalization or treatment in acute care outpatient setting in the month prior to enrollment * Subject requires a program of prescheduled regularly administered packed red blood cell (pRBC) transfusions or Subject received a pRBC transfusion in the month prior to enrollment * Subject has evidence of latent or active tuberculosis * Subject has a major concurrent illness or medical condition * Subject is pregnant or nursing