The aim of this study is to evaluate the signs of nephronic reduction in preterm infants who have presented neonatal acute renal failure. The investigators hypothesize that signs of nephronic reduction would appear earlier in former preterm with neonatal acute renal failure than in control preterm infants.
50 former preterm infants who presented acute renal failure will be evaluated between 3 to 10 years. They will be compared to 25 control former preterm infants without renal dysfunction for signs of nephronic reduction. At inclusion, in order to analyse renal function, all infants will have blood sampling, renal echography and blood pressure measurement. Urine sample will also be collected. Two months later, parents will be informed on the results.
Study Type
INTERVENTIONAL
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
75
renal echography to analyse the kidney
Blood sampling to analyse different parameters of renal function
Collection of an urine sample to perform analysis of renal function parameters
CHU of Nantes
Nantes, France
microalbuminuria
The primary outcome of this study is to prove that former preterm infants with neonatal acute renal failure are at higher risk of nephronic reduction than control former preterm infants and that they will present microalbuminuria as earlier sign of nephronic reduction. Precisely, if microalbuminuria divided by creatinuria is above 20mg/g or 2mg/mmol, it will be considered as pathologic.
Time frame: Day 1 (at inclusion)
measurement of blood pressure
Evaluation of other renal parameters: blood pressure, renal filtration, tubular functions evaluation of renal size and differentiation by ultrasound
Time frame: Day 1 (at inclusion)
measurement of length and volume of kidney by renal echography
Time frame: day 1
creatinine clearance
Time frame: day 1
calciuria
Time frame: Day 1
sodium clearance
Time frame: day 1
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