Study of Cisatracurium and Sufentanil Consumption Using a Closed Loop Computer Control Infusion System

Tianjin Medical University General Hospital150 enrolled

Overview

The purpose of this study is to: * determine the effect of dexmedetomidine on cisatracurium infusion requirements and sufentanil consumption. * analyze the cisatracurium infusion requirements and sufentanil consumption in different age groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

150

Conditions

The Intraoperative Effect of Dexmedetomidine on Cisatracurium Infusion Consumption and Its Recovery Index.Effect of Dexmedetomidine on Sufentanil Consumption.Quantitative Analysis of Cisatracurium Infusion Requirements, Sufentanil Consumption and Recovery Index in Different Age Groups.

Interventions

Effect of dexmedetomidine on cisatracurium and sufentanil consumptionDRUG

In this intervention we compared the cisatracurium consumption, recovery index and sufentanil consumption between P2 and D. The reason we are comparing patients in group D with P2 is that because they belong to the same age group.

Consumption of cisatracurium and sufentanil in different age groups.DRUG

For this intervention, we compared the cisatracurium consumption, refractory index and sufentanil consumption between group P1, P2 and P3.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ASA status 1 and 2. * Consent approval written and oral. * Patients scheduled for elective abdominal surgery under general anesthesia. Exclusion Criteria: * Patients with neuromuscular disorders. * Patients with history of stroke, flaccid paralysis or other neurological disorders. * Significant renal, hepatic or cardiac dysfunction. * Consent refusal.

Outcomes

Primary Outcomes

Cisatracurium infusion consumption.

Measurements were done during the operation. Cisatracurium infusion was controlled a closed loop computer system. The degree of neuromuscular blockage was assessed every 20 seconds throughout the procedure using the train of four testing. It was done by counting the number and amplitude of twitches evoked after electrical stimulus and the rate of infusion maintained itself at the low rate of 0.20µg/kg/min as long as the T1 response is less than 1%. When the T1 \> 1%, the rate of infusion would automatically increase to 5.0 µg/kg/min until T1 \< 1%, after which the infusion rate would fall back to 0.20µg/kg/min. The controlled infusion described above administered small doses of cisatracurium intra-operatively to maintain a muscle relaxation of more than 99%. The system saved the time and amount of drug given throughout the operation, from which the consumption was calculated in µg/kg/min.

Time frame: At the time of surgery

Secondary Outcomes

Sufentanil consumption.

Analgesia was maintained by intermittent bolus dose of 10-20 µg of Sufentanil when the pulse and blood pressure would increase by more than 20% of the baseline, and BIS in the required range, as this would indicate an increase perception of pain but adequate anaesthesia. Sufentanil consumption was calculated for each patient in µg/kg/hr and the length of the operation was determined as from induction to the time of skin closure.

Time frame: At the time of operation.