Renal Sympathetic Denervation and Insulin Sensitivity (RENSYMPIS Study)

Inclusion Criteria: * Resistant Hypertension (systolic blood pressure \>160mmHg and 3 or more antihypertensive agents in use) * Age 30- 69 years * Written informed consent Exclusion Criteria: * Secondary hypertension * Pseudohypertension * Pregnancy * Renal insufficiency (GFR \<45ml/min) * Clinically significant stenotic valvular disease * Oral anticoagulation * CCS III-IV symptoms or CABG/PCI in previous 6 months * Prior stroke * Contrast agent allergy * inappropriate renal artery anatomy (\< 4mm diameter, \< 20mm length)