A Study to Evaluate ITCA 650 for the Treatment of Type 2 Diabetes in Patients With High Baseline HbA1c

Inclusion Criteria: * Men or women age 18 to 80 years with type 2 diabetes * On stable treatment regimen of diet and exercise alone or in combination with a stable \& optimal or near-optimal dose of metformin, sulfonylurea, TZD or combination of these drugs * HbA1c \>10.0% and ≤12.0% Exclusion Criteria: * Prior treatment with any GLP-1 receptor agonist * History of hypersensitivity to exenatide or liraglutide * FPG \>300 mg/dL * History of medullary thyroid cancer or a family or personal history of multiple endocrine neoplasia type 2 * Taking DPP-4 inhibitors, incretin mimetics, alpha glucosidase inhibitors, meglitinides or insulin within last 3 months * history of pancreatitis