Testogel® (Testosterone Gel 50mg/5g) in the Treatment of Male Hypogonadism

Inclusion Criteria: * Male ages 18-68 years diagnosed as having testosterone deficiency with clinical symptoms * A morning (8:00-10:00) serum Total Testosterone concentration of ≤ 300 ng/dL, confirmed by a second measurement of morning serum Total Testosterone concentration ≤ 300 ng/dL (samples to be taken 1 - 3 weeks apart) Exclusion Criteria: * Abnormal prostate as evidenced by prostatic symptoms, prostatic masses or induration on rectal examination, or elevated levels of prostate specific antigen (PSA \> 4ng/ml) or a maximum urine flow rate of less than 12 ml/sec(of a urine volume greater than 150ml) (and/or an International Prostate Symptom Score IPSS score \>19) * Hematocrit \> 50% * Major psychiatric illness * Unable to understand the protocol or to give informed consent * Use of paroxetine and clomipramine * Active alcoholism * History of drug abuse within the past five years; * Use of drugs that might interfere with the results of the study (e.g., antiandrogen, estrogens or P 450 enzyme inducers, barbiturates); * BMI \< 18 or \> 30 according to Chinese BMI references; * Generalized skin disease that may affect absorption of T (e.g., psoriasis) or a known skin intolerance to alcohol; * Prolactin \> 40 mcg/L; * Untreated severe obstructive sleep apnea;. * Uncontrolled or poorly controlled heart failure