Polymorphism of beta2-adrenoceptor and Regular Use of Formoterol in Asthma

Catholic University, Italy30 enrolled

Overview

Polymorphism at codon 16 of the beta2-adrenoceptor (beta2-AR) affects the responsiveness to salmeterol in asthmatics. Data concerning formoterol are more controversial in literature. The aim of this study was to verify whether homozygote for arginine-16 (ArgArg16) and homozygote for glycine-16 (GlyGly16) genotypes differently influence the long-term responsiveness to formoterol.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Asthma

Interventions

FormoterolDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Mild to moderate asthma * Stable clinical conditions Exclusion Criteria: * Smokers * Current therapy with oral steroids * Exacerbations within the past 3 months

Locations (1)

Catholic University, Pneumology Unit

Rome, Italy

Outcomes

Primary Outcomes

Peak Expiratory Flow (PEF) variability

Time frame: PEF has been monitorized during the 4-week treatment period

Secondary Outcomes

Forced Expiratory Volume in 1 sec (FEV1) slope of the dose-response curve to salbutamol

Time frame: At the end of the 4-week treatment period

Data from ClinicalTrials.gov

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