Acid-suppressing Drugs Pregnancy Asthma Offspring Study

AstraZeneca10,116 enrolled

Overview

The purpose of this study is 1. To estimate the association between prenatal exposure to proton pump inhibitors (PPIs) and the risk of asthma during childhood. 2. To estimate the association between prenatal exposure to H2-receptor antagonists (H2RAs) and the risk of asthma during childhood.

A cohort study on the association between acid-suppressing drugs in pregnancy and asthma in the offspring

Study Type

OBSERVATIONAL

Enrollment

10,116

Conditions

Asthma in Offspring

Interventions

Risk of asthma in offspringDRUG

Exposure to PPI or H2RA, respectively during pregnancy No exposure to acid suppressing drugs during pregnancy

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: \- Females aged 18-45 years with at least one pregnancy between 1 January 1995 - 31 December 2010 (see study population description) Exclusion Criteria: \- Males, females below age 18 and 45 years and above (see study population description)

Locations (1)

Research Site

Madrid, Spain

Outcomes

Primary Outcomes

Relative risk of first asthma diagnosis associated with prenatal exposure to proton pump inhibitors

Time frame: From 1 January 2005 till 31 December 2010, an expected average of 5 years.

Relative risk of first asthma diagnosis associated with prenatal exposure to histamine-2 receptor antagonists

Time frame: From 1 January 2005 till 31 December 2010, an expected average of 5 years

Data from ClinicalTrials.gov

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