The Use of Zoledronic Acid to Complex Regional Pain Syndrome

Inclusion Criteria: 1. Patients over 18 years of age of both genders, with continuing pain that is disproportionate to any inciting event, with cardinal features of CRPS. 2. Pain - after initial injury with signs and symptoms present at first visit 3. History of previous unsuccessful treatment for pain, with a minimum of two drug therapies, such as non steroidal anti-inflammatory drugs, steroids, antidepressants, central acting analgesics, calcitonin or sympathetic blocks, (not bisphosphonates) for at least six months. 4. Must report at least one symptom in three of the four following categories: 1. Sensory: Reports of hyperesthesia and/or allodynia 2. Vasomotor: Reports of temperature asymmetry and/or skin color changes and/or skin color asymmetry 3. Sudomotor/Edema: Reports of edema and/or sweating changes and/or sweating asymmetry 4. Motor/Trophic: Reports of decreased range of motion and/or motor dysfunction (weakness, tremor, dystonia) and/or trophic changes (hair, nail, skin). 5. Must display at least one sign\* at time of evaluation in two or more of the following categories: 1. Sensory: Evidence of hyperalgesia (to pinprick) and/or allodynia (to light touch and/or deep somatic pressure and/or joint movement) 2. Vasomotor: Evidence of temperature asymmetry and/or skin color changes and/or asymmetry 3. Sudomotor/Edema: Evidence of edema and/or sweating changes and/or sweating asymmetry 4. Motor/Trophic: Evidence of decreased range of motion and/or motor dysfunction (weakness, tremor, dystonia) and/or trophic changes (hair, nail, skin). 6. Skin temperature of the affected side equal or higher than on the non-affected side. 7. No other diagnosis better explains the signs and symptoms. Exclusion Criteria: 1. Presence of systemic diseases including diabetes mellitus, hyperthyroidism, renal and liver dysfunction, peripheral vascular or cardiovascular diseases, uncontrolled hypertension, rheumatoid and hematopoietic diseases, neurological diseases not related to CRPS, overt alcohol addiction, positive pregnancy test and/or lactating women, hyperparathyroidism, and hypocalcaemia. 2. Creatinine clearance \<35mL/min, with serum creatinine measured before the dose of zoledronic acid. 3. Pre-existing hypocalcaemia and disturbance of mineral metabolism (e.g. hyperparathyroidism, thyroid surgery, parathyroid surgery, malabsorption syndromes, and excision of small intestine). 4. Hypersensitivity to zoledronic acid or any component drugs used in the trial. 5. Patients with asthma and aspirin-sensitivity 6. Pregnancy or unwillingness to use contraceptive methods during the trial 7. Patients who have previously used any kind of bisphosphonate, especially zoledronic acid. 8. Osteoporosis