HPV in Adolescents

The HIV Netherlands Australia Thailand Research Collaboration27 enrolled

Overview

This study will assess the prevalence of HPV infection in perinatally HIV-infected adolescents, intraepithelial neoplasia, and E6E7 biomarker at cervical and anal sites.

Human Papillomavirus (HPV) is the most common sexually transmitted disease and it causes cervical and anal cancer. Prevalence and incidence of HPV infection among young adults who are sexually experienced is high. No data exist for HIV-positive adolescents in regards to HPV infection, cervical and anal intraepithelial neoplasia. This study will compare the prevalence of HPV infection, intraepithelial neoplasia and E6/E7 biomarker at cervical and anal sites among perinatally HIV-infected adolescents, behaviorally HIV-infected adolescents, and HIV-negative adolescents.

Study Type

OBSERVATIONAL

Enrollment

Conditions

HPV Infection Cervical/Anal Dysplasia

Eligibility

Sex: ALLMin age: 12 YearsMax age: 24 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Perinatally-infected (documented positive HIV enzyme immunoassay (EIA) or nucleic acid testing (NAT) at any time and history of maternal HIV infection) * behaviorally-infected (documented positive HIV enzyme immunoassay (EIA) or nucleic acid testing (NAT) at any time after sexual debut without history of maternal HIV infection) * female with vaginal or receptive anal intercourse with a male OR male with receptive rectal intercourse with another male * Signed informed consent. Volunteers aged 12-17 years can decide whether they wish for their parents to consent for their participation. Due to the confidential nature of the issues being studied, parental consent may be exempted Exclusion Criteria: * Have any conditions that may interfer with subjects' ability to understand and consent to the study

Locations (3)

Department of Pediatrics, Chulalongkorn University

Bangkok, Thailand

HIV-NAT

Bangkok, Thailand

Thai Red Cross - Anonymous Clinc

Bangkok, Thailand

Outcomes

Primary Outcomes

HPV infection

Prevalence of cervical and anal HPV infection and of oncogenic subtypes, among perinatally HIV-infected adolescents, behaviorally HIV-infected adolescents, and HIv-negative adolescents

Time frame: 48 weeks

Secondary Outcomes

intraepithelial neoplasia

Prevalence of intraepithelial neoplasia among the three study groups and in male and female subjects

Time frame: 48 weeks

E6/E7

Prevalence of detected E6/E7 biomarker among the tree study groups and in male and female subjects. Correlation between detected E6/E7 and presence of HPV infection and/or intraepithelial neoplasia Association between HAART use, CD4 counts, plasma HIV RNA level and HIV clinical staging with HPV infection, intraepithelial neoplasia and E6/E7 detection

Time frame: 48 weeks

HPV vaccine

Proportion of adolescents who would benefit from the current preventive vaccine (i.e. those who have not been infected with oncogenic HPV subtypes 16 and 18)

Time frame: 48 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.