PI3K(phosphatidylinositol 3-kinase)/AKT pathway is an important oncogenic signaling pathway. However, clinical information about the significance of p-AKT expression in malignant lymphoma is not fully understood yet. In this study, we investigated the overexpression of p-AKT and its prognostic implication in malignant lymphoma.
Recently, among diverse oncogenic signaling pathways, a number of studies have focused on the significance of oncogenic PI3K/AKT (phophatidylinositol 3-kinase/serine-threonine kinase, also known as protein kinase B \[PKB\]) pathway. PI3K(phosphatidylinositol 3-kinase)/AKT pathway phosphorylates and activates AKT as phosphorylated AKT (p-AKT) and plays a critical role promoting malignant phenotype and has prognostic significance in various solid cancers. However, a systematic approach on the impact of p-AKT overexpression on clinical outcomes has not been performed in malignant lymphoma.
Study Type
OBSERVATIONAL
Enrollment
262
p-AKT staining on the adequate paraffin-embedded biopsy specimen or unstained slides
Samsung Medical Center
Seoul, South Korea
Difference of overall survival according to p-AKT status in malignant lymphoma
Time frame: study entry
Subgroup analysis of overall survival according to histologic subtypes (GCB vs non GCB)
Time frame: study entry
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