Urinary Excretion of Anthocyanins During Long Term Blueberry Feeding

Atlantic Food and Horticulture Research Center17 enrolled

Overview

Essentially all of the published data on anthocyanin absorption in humans are from short term studies - a few days or less, most typically 24 h. However human studies demonstrating clinical effects are typically conducted for several weeks or even months. To examine how anthocyanin absorption and metabolism may be affected this study will examine urinary excretion of anthocyanins over one month, followed by a one week washout, and then one more dose of blueberry juice.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Bioavailability

Interventions

Blueberry JuiceOTHER

Dietary intervention

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Provided written consent (see: Information and Consent Form) * Fluent in English * Complete a confidential medical questionnaire (Appendix 6) * Able and willing to abide by the dietary restrictions as described * Able and willing to abide by the urine collection protocols as described Exclusion Criteria: * No written consent * No confidential medical questionnaire * Unable to comply with diet restrictions and other study requirements

Locations (1)

Atlantic Food & Horticulture Research Centre

Kentville, Nova Scotia, Canada

Outcomes

Primary Outcomes

Anthocyanins and Phase 2 anthocyanin conjugates in urine

Time frame: 5 weeks

Secondary Outcomes

White blood cell gene expression at start and end of study

Time frame: 4 weeks

Data from ClinicalTrials.gov

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