Real-time Comparison of Left Ventricular Strokevolume Measurement by Four Different Methods

University Hospital, Linkoeping20 enrolled

Overview

Real-time comparison of three different bedside strokevolumemeasurements (arterial waveform analysis, eosofageal doppler and 2D transthoracal ultrasound) validated against cardiac magnetic resonance imaging (CMRI)

20 healthy volounteers between age of 20-40 years, no previous medical history undergo simoultaneous left ventrikular strokevolume measurements using three different methods at rest. After datasampling and without moving, the subject then undergo Cardiac Magnetic Resonance Imaging with 2D-throughplane and cine tecnology for validation of volume measurements. The data is then analyzed using Bland-Altman calculation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Difference in Measured Results Using Four Different Strokevolume Measurements Simultaneously.

Interventions

Arterial waveform analysis, esofageal doppler, transthoracal cardiac ultrasound, Cardiac magnetic resonance imaging.PROCEDURE

Eligibility

Sex: ALLMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria:Healthy volounteers age 20-40, BMI \< 30, weight \< 100 kg, no medications, sinus rythm on ECG, no contra-indications for MRI, ability to give written informed consent. \- Exclusion Criteria: * Heart and/or vascular disease such as angina pectoris, arrythmias, claudicatio intermittens e g. * Diseases in gastrointestinal tract or nose. * Coagulopathies * Pregnancy * Allergys for local anaesthetics * Claustrofobia

Locations (1)

Departement for intensive care medicine, Universitetssjukhuset

Linköping, Sweden

Outcomes

Primary Outcomes

Limits of agreement (LOA) is less than 30% using CMRI as validation for each individual measurement of left ventricular stroke volume.

Time frame: Study period (1 month)

Data from ClinicalTrials.gov

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