Effect of Metoclopramide Versus Sumatriptan for Emergency Department Treatment of Migraine Headache

Isfahan University of Medical Sciences124 enrolled

Overview

The purpose of this study is to determine which drug makes lower migraine headache

There are different options to manage benign headache in emergency department.The investigators compared Intravenous metoclopramide with Subcutaneous sumatriptan to relieve pain in emergency department.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

124

Conditions

Migraine Disorders

Interventions

metoclopramide, injection,20mg, one timeDRUG

metoclopramide, intravenous injection,20mg, one time

Sumatriptan, injection, 6 mg, one timeDRUG

Sumatriptan, subcutaneous injection, 6 mg, one time

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 20-60 years old and presented with acute headache similar to previous episodes, * with or without phonophobia, * photophobia, * vomiting or nausea. Exclusion Criteria: * fever or neck stiffness, * altered mental state, * pregnancy, * recent trauma or seizure (within 24 hours), * focal neurological abnormality on physical examination, * allergy to metoclopramide, * hypertension, * cardiovascular diseases. Also if the patients had taken a triptan or ergot during the last 24 hours were excluded from the study.

Locations (1)

Al-zahra university hospital

Isfahan, Isfahan, Iran

Outcomes

Primary Outcomes

pain

determining pain in Metoclopramide versus sumatriptan groups

Time frame: at one hour after prescription

Data from ClinicalTrials.gov

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