Acute respiratory infection and acute diarrhea are among the most prevalent diseases of childhood increase the burden of morbidity and mortality in children under 5 years. Among the possible strategies for its prevention is important to count on good nutritional status for use in developing a good immune response to infections. Zinc deficiency has been shown to favor the development of infections and has been considered a real public health problem. Within the zinc compounds used are zinc amino acid chelate and zinc sulphate, the first that has shown evidence of being better absorbed and tolerated. We propose a study showing the effectiveness of zinc amino acid chelate and zinc sulphate in the prevention of acute diarrheal disease and acute respiratory infection.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
360
Zinc sulfate as dietary supplementation
Zinc amino acid chelate as dietary supplementation
Milk without fortification
CES University
Medellín, Antioquia, Colombia
Incidence acute diarrheal disease and acute respiratory infection
Preschool children will drink fortified milk with zinc amino acid chelate, zinc sulfate or milk without fortification. Fortnightly monitoring will be investigating the presence of infection (acute diarrheal disease and respiratory infections). Supervision and monitoring will be carried out for four months.
Time frame: Up to 16 weeks
Adverse reaction
The caregiver recorded daily if the child had an adverse reaction such as abdominal pain, nausea and vomiting.
Time frame: Fortnightly. During 4 months of intervention
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