The Effects of Synbiotics Supplement on Biochemical Factors and Hepatic Fibrosis in Patients With Nonalcoholic Steatohepatitis

Inclusion Criteria: * Age of 18 to 70 years * Body Mass Index (BMI) between 25-40 * Serum alaninaminotransferase more than 1.5 fold of upper limit of normal range * Sonographic findings compatible with hepatic steatosis (degree 2 or more) Exclusion Criteria: * Diabetes * Taking any kind of antibiotics two weeks before recruitment * History of alcohol consumption * pregnancy or lactation * Professional athletes * Other liver disease (viral/etc) * Use of drugs such as calcium channel blockers, high dose synthetic estrogens, methotrexate , amiodarone, steroids, chloroquine, immunosuppressive drugs, lipid-lowering agents, metformin and vitamin E * A history of Hypertension, Cardiovascular disease, Pulmonary disease, Renal disease \& Celiac disease; Cirrhosis * History of Upper GI surgery / Prior surgical procedures such as jejunoileal or jejunocolic bypass, gastroplasty * Following program to lose weight in recent 3 mo * A history of hypothyroidism or Cushing's syndrome