This pilot clinical trial studies magnetic resonance thermal image guided laser interstitial thermal therapy in treating patients with breast cancer. Magnetic resonance thermal image guided laser interstitial thermal therapy may be able to kill tumor cells by heating up the tumor cells without affecting the surrounding tissue
PRIMARY OBJECTIVES: I. To evaluate the procedural success rate of using the Visualase magnetic resonance (MR)-guided laser system to target, access, thermally monitor, and focally ablate MR-visible breast cancer lesions. 2\. To obtain preliminary data on ablative success using pathologic assessment for specimen excised subsequent to the ablation. OUTLINE: Patients undergo MR-thermal image guided laser interstitial thermal therapy (LITT) over 1 hour. After completion of study treatment, patients are followed up at 3-7 days.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Undergo MR-thermal image guided LITT
Undergo MR-thermal image guided LITT
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States
Frequency of not completing the procedure due to patient's discomfort
Time frame: Up to 7 days
Observed thermal damage on skin
Moderate degree of skin burn which requires medical intervention will be considered side effects for stopping purposes.
Time frame: Up to 7 days
Grade 3 or 4 toxicities assessed by the National Cancer Institute (NCI) Common Toxicity Criteria (CTC)
Time frame: Up to 7 days
Amount of tumor necrosis
Time frame: Up to 7 days
Amount of viable tumor
Time frame: Up to 7 days
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