Measuring Corneal Cells With Specular Microscopy

Retina Institute of Hawaii30 enrolled

Overview

Assess changes in the corneal cell count using Specular Microscopy following tretments with Anti-VEGF injections

Patients with active Wet AMD often receive intraocular Anti-VEGF injections such as Macugen, Lucentis and Avastin on a monthly basis for an extended period of time. While these medications are very effective at controlling the Choroidal Neovascularization associated with this disease, the impact of monthly intravigtreal Anti-VEGF injections on the viability of corneal endothelial cells has yet to be fully characterized. The availability of CESM as a diagnostic test that can be performed quickly and painlessly in the clinic offers a method of tracking corneal endothelial cell count in this patient population.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Retinal Diseases

Eligibility

Sex: ALLMin age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Wet Age-related Macular Degeneration * Receiving monthly intraocular injections of Anti-VEGF medication for at least 3 months * Age greater than 50 years of age Exclusion Criteria: * experiences adverse events

Locations (1)

Retina Institute of Hawaii

Honolulu, Hawaii, United States

Outcomes

Primary Outcomes

Specular Photomicrographic Assessment of the Effect of Anti-VEGF Intravitreal injections on corneal thickness and endothelial cell density and morphology

Changes in corneal endothelial cell density and corneal thickness measured by changes in pachymetry and corneal cell count.

Time frame: Baseline, Month 6 and Month 12

Data from ClinicalTrials.gov

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