Bovine colostrum is the initial milk secreted by cows during the first day after calving. Colostrum is high in protein and contains a number of substances that have potential to be beneficial for the immune system. Preliminary studies about effects of colostrum supplementation show its potential for increasing human exercise performance; however, more evidence across the lifespan is required to confirm effects and to understand mechanisms of action. The objectives are to determine the effect of 8 weeks of bovine colostrum supplementation, compared to whey protein supplementation on the following dependent variables in men and women 50 years and older while participating in a resistance-training program: * muscle mass * strength * blood levels of growth factors and markers of inflammation * urine levels of muscle and bone catabolic markers * tests of cognitive ability It is hypothesized that bovine colostrum supplementation will result in greater increases in muscle mass, strength, blood IGF-1 levels (an anabolic hormone), and cognitive ability, and greater reductions in inflammation, and markers of muscle and bone catabolism, compared to placebo.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
40
College of Kinesiology, University of Saskatchewan
Saskatoon, Saskatchewan, Canada
change from baseline in lean tissue mass at 8 weeks
Lean tissue mass assessed by dual energy x-ray absorptiometry
Time frame: baseline and 8 weeks
Change from baseline in Upper body strength at 8 weeks
Bench Press Strength
Time frame: baseline and 8 weeks
Change from baseline in Lower body strength at 8 weeks
Leg press strength
Time frame: baseline and 8 weeks
Change from baseline in Insulin like growth factor-1 at 8 weeks
IGF-1 from serum
Time frame: baseline and 8 weeks
Change from baseline in upper body muscle thickness at 8 weeks
Muscle thickness of the elbow flexors assessed by ultrasound
Time frame: baseline and 8 weeks
Change from baseline in lower body muscle thickness at 8 weeks
Knee extensors muscle thickness assessed by ultrasound
Time frame: baseline and 8 weeks
Change from baseline in muscle catabolism at 8 weeks
Urinary 3-methylhistidine levels
Time frame: baseline and 8 weeks
Change from baseline in bone catabolism at 8 weeks
Urinary cross-linked N-telopeptides of type I collagen
Time frame: Baseline and 8 weeks
Number of Participants with Adverse Events as a Measure of Safety and Number of Participants with Adverse Events as a Measure of Safety and Tolerability
Adverse events collected on adverse event forms
Time frame: continuously throughout 8 weeks
Change from baseline in inflammation at 8 weeks
Serum cytokine markers of inflammation (IL-6 and TNF-alpha)
Time frame: baseline and 8 weeks
Change from baseline in cognitive ability at 8 weeks
The Telephone Interview of Cognitive Status
Time frame: baseline and 8 weeks
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