Registry Trial to Determine pCLE Image Interpretation Criteria and Preliminary Accuracy in the Lung

Inclusion Criteria: * Male or female \> 18 years of age * Willing and able to comply with study procedures and provide written informed consent to participate in the study * Indeterminate discrete nodule(s) suspicious for cancer scheduled for diagnostic bronchoscopy * Newly discovered \&/or prior discovered non classified nodules, hard to define based on CT scan * Purpose of bronchoscopy is for diagnosis of lesion(s) - can be solitary pulmonary nodule or multiple lesions * All lesion locations are acceptable * Any patient undergoing clinically indicated bronchoscopies after lung transplantation * Patients post transplant showing clinical signs of acute rejection \>3 weeks; \< 1 year * Patient with single or double lung transplant Exclusion Criteria: * Contraindication to short-acting anesthetic agents; * Contraindications to transbronchial biopsy * Bleeding diathesis; * A pacemaker/defibrillator; * A diagnosis by other means (sputum cytology, microbiology). * Unwilling To Consent * Unable To Safely Tolerate A Bronchoscopic Procedure * Unwilling To Comply With Surveillance Bronchoscopy Follow Up * Chronic Rejection * Fungal Disease * Ax Histological Assessment Or Incomplete Biopsy Procedure Should Be Considered As A Screen Failure