Hyperoxic Oxidative Stress During Abdominal Surgery

Istanbul University40 enrolled

Overview

Our aim is to compare the effects of 80% and 40% Fraction of inspired oxygen on oxidative stress, antioxidant response (in plasma and bronchoalveolar lavage), extubation quality, preanesthetic and postanesthetic expiration tidal volumes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Response to Hyperoxia

Interventions

Fraction of inspired oxygen 40%OTHER

Fraction of inspired oxygen 80%OTHER

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing abdominal surgery, between 20-60 years old, with American Society of Anesthesiology score I or II Exclusion Criteria: * Patients with Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, muscle-bone diseases, inflammatory bowel diseases and patients with malnutrition. Patients will be recruited through general surgery service of our hospital

Locations (1)

Cerrahpasa Medical Faculty Anesthesiology and Reanimation Department

Istanbul, Fatih, Turkey (Türkiye)

Outcomes

Primary Outcomes

oxidant and antioxidant response

As primary outcome, the effects of different inspired oxygen fractions on oxidative stress and anti-oxidant response in plasma and bronchoalveolar lavage after intubation and prior to extubation will be evaluated

Time frame: 4 hours

Secondary Outcomes

Hemodynamics

The secondary outcome was evaluating the effects of different inspired oxygen fractions on hemodynamics.

Time frame: 4 hours

Data from ClinicalTrials.gov

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