Benefits of Exercise Training in Head and Neck Cancer Patients Undergoing Organ-Preserving Definitive Therapy

Inclusion Criteria: * Patients with American Joint Committee on Cancer (AJCC) stage II-IV head and neck squamous cell carcinoma who are beginning first-line non-surgical treatment with radiotherapy (with or without chemotherapy or targeted agents), and who are capable of understanding and adhering to the protocol requirements. * Patients must be willing to comply with the study procedures and visits Exclusion Criteria: * Active cardiopulmonary disease * Substantial dementia (based on Folstein Mini Mental State Examination \<24 out of 30) * Acute medical conditions, such as acute flare-up of joint condition or infection * Participants must not be actively receiving physical therapy, at time of enrollment, or actively exercising 2 or more hours a day, with the intent to continue that regimen * Patients refusing a percutaneous endoscopic gastrotomy (PEG) Tube needed for nutrition, as determined necessary by treating physician * Patients are actively being treated for another cancer at the time of enrollment.