The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal Dystrophy

Universitaire Ziekenhuizen KU Leuven460 enrolled

Overview

The purpose of this study is to gain further insights into the molecular pathogenesis of Fuchs' endothelial corneal dystrophy (FECD), to identify targets for potential specific drug therapy.

Study Type

OBSERVATIONAL

Enrollment

460

Conditions

Fuchs' Endothelial Dystrophy

Interventions

No interventionOTHER

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * FECD * normal corneas (including enucleations for uveal melanoma) * non-FECD oedematous corneas Exclusion Criteria: * prior irradiation therapy for uveal melanoma * corneal extension of uveal melanoma

Locations (1)

Department of Translational Cell and Tissue Research - campus Sint-Raf - UZ Leuven

Leuven, Belgium

Outcomes

Primary Outcomes

cytokine levels

dosage of cytokine levels in aqueous humour (exploratory, non-interventional study)

Time frame: at time of prelevation (once, no intervention)

gene expression levels

microarray expression analysis, reverse transcriptase - quantitative polymerase chain reaction (RT-qPCR), RNA-sequencing (exploratory, non-interventional study)

Time frame: at time of prelevation (once, no intervention)

protein content

immunohistochemistry and immunofluorescence

Time frame: at time of prelevation (once, no intervention)

Data from ClinicalTrials.gov

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