The Impact of Liraglutide on Glucose Tolerance and the Risk of Type 2 Diabetes in Women With Previous Pregnancy-induced Diabetes

Inclusion Criteria for women with previous GDM: * Informed oral and written consent * Previous diagnosis of GDM according to current Danish guidelines (mainly PG concentrationa t 120 min after 75 g OGTT ≥ 9.0 mM) during pregnancy within the last 5 years * Age \>18 years * 25 kg/m2 \< BMI \< 45 kg/m2 * NGT, IFG and or IGT * Safe contraception and negative pregnancy test Exclusion Criteria for women with previous GDM: * Patients with diabetes * HbA1c ≥6.5% * Patients with previous pancreatitis or previous neoplasia * Pregnant or breast feeding women * Anaemia (haemoglobin \<7 mM) * Women planning to become pregnant within the next 5 years * Women using other contraception than intrauterine device (IUD) or oral contraceptives. Women who do not use safe contraception will be offered application of an IUD. * Women treated with statins, corticosteroids or other hormone therapy (except estrogens and gestagens) * Ongoing abuse of alcohol or narcotics * Impaired hepatic function (liver transaminases \>3 times upper normal limit) * Impaired renal function (se-creatinine \>120 μM and/or albuminuria) * Uncontrolled hypertension (systolic blood pressure \>180 mmHg, diastolic blood pressure \>100 mmHg) * Any condition that the investigator feels would interfere with trial participation * Receiving any investigational drug within the last 3 months Inclusion criteria for women without previous GDM: * Informed oral and written consent * Age \>18 years * 25 kg/m2 \< BMI \< 45 kg/m2 * NGT * Safe contraception and negative pregnancy test * Pregnancy within the last ten years without GDM Exclusion Criteria for women without previous GDM : * Pregnant or breast feeding women * Anaemia (haemoglobin \<7 mM) Inclusion Criteria for women without previous GDM and without NAFLD: * Informed oral and written consent * Age \>18 years * 25 kg/m2 \< BMI \< 45 kg/m2 * NGT * At least one pregnancy witin the last ten years without GDM Exclusion Criteria for women without previous GDM and without NAFLD: * Pregnant or breast feeding women * Anaemia (haemoglobin \<7 mM) * Steatosis as assessed by ultrasound scanning * Recieving any investigational drug within the last 3 months * Any condition that the investigator feels would interfere with the trial participation Inclusion Criteria for women with biopsi-verified NAFLD: * Informed oral and written consent * Women with known NAFLD or NASH * Age \>18 years * 25 kg/m2 \< BMI \< 45 kg/m2 * NGT * At least one prior pregnancy Exclusion Criteria for women with biopsi-verified NAFLD: * women with established cirrhosis * Pregnant or breast feedning women * Anaemia (haemoglobin \<7 mM) * Women treated with statins, corticosteroids or other hormone therapy ( except oestrogens and gestagens) * Ongoing abuse of alcohol or narcotics * Impaired renal function (se-creatinine \> 120 μM and/or albuminuria) * Uncontrolled hypertension (systolic blood pressure \> 180 mmHg, diastolic blood presure \> 100 mmHg) * Any condition that the investigator feels would interfere with trial participation