Phase I Study Evaluating the Treatment of Patients With Locally Advanced Pancreatic Cancer With Carbon Ion Radiotherapy: The PHOENIX-01 Trial

Inclusion criteria Patients meeting all of the following criteria will be considered for admission to the trial: * histologically confirmed locally advanced pancreatic cancer or imaging defined pancreatic cancer combined with elevated CA-19-9 * macroscopic tumor after biopsy * age ≥ 18 years of age * Karnofsky Performance Score \>=60 * For women with childbearing potential, (and men) adequate contraception (sexual abstinence, estrogen- or gestagen containing contraceptive medication etc.) * Female participants: No pregnancy present (pregnancy test required) * Ability of subject to understand character and individual consequences of the clinical trial * Written informed consent (must be available before enrolment in the trial) Exclusion criteria: Patients presenting with any of the following criteria will not be included in the trial: * distant metastases * refusal of the patients to take part in the study * previous radiotherapy of the abdomen * Patients who have not yet recovered from acute toxicities of prior therapies * Known carcinoma \< 5 years ago (excluding Carcinoma in situ of the cervix, basal cell carcinoma, squamous cell carcinoma of the skin) requiring immediate treatment interfering with study therapy * Pregnant or lactating women * Participation in another clinical study or observation period of competing trials, respectively