The Effect of Simulated Obstructive Apnoea and Hypopnoea on Heart Rhythm in Patients With Paroxysmal Atrial Fibrillation

University of Zurich45 enrolled

Overview

In this randomised controlled cross-over study we will investigate whether intrathoracic pressure changes induced by simulated obstructive apnoea and hypopnoea trigger premature supraventricular and ventricular contractions as well as atrial fibrillation in patients with paroxysmal atrial fibrillation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

DOUBLE

Enrollment

Conditions

Patients With Paroxysmal Atrial Fibrillation

Interventions

Mueller manoeuvreOTHER

Inspiratory thresholdOTHER

Expiratory apnoeaOTHER

Steady state normal breathingOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion criteria: * Age 18-75 years * History of ECG-documented paroxysmal atrial fibrillation within the last 12 months and currently in sinus rhythm * Informed consent Exclusion criteria: * Mental or physical disability precluding informed consent or compliance with the protocol * Amiodarone or Dronedarone medication * Previous radiofrequency ablation for atrial fibrillation * Severe structural heart disease

Locations (1)

University Hospital Zurich, Division of Pneumology

Zurich, Canton of Zurich, Switzerland

Outcomes

Primary Outcomes

Number of subjects with premature myocardial contractions and/or atrial fibrillation

Time frame: 20 seconds

Secondary Outcomes

ECG-derived myocardial de- and repolarization times

Time frame: 20 seconds

Data from ClinicalTrials.gov

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