Relationship Between PTEN and Glycemic Variability and Outcome in Critically Ill Patients

University of Roma La Sapienza20 enrolled

Overview

Glycemic variability in critically ill patients is a recognized negative prognostic factor. The molecular mechanisms determining inter-patients variability in glucose metabolism during stress are not fully understood. The Phosphatase and Tensin homolog (PTEN) is known to influence glucose homeostasis by interfering in intracellular insulin signaling. Aim of this study is to ascertain whether differential expression of PTEN in critically ill patients correlates with glycemic variability and clinical outcome.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Critical Illness Hyperglycemia

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * trauma * provision informed consent Exclusion Criteria: * diabetes * impaired fasting glucose levels

Locations (1)

University of Rome La Sapienza, University Hospital

Rome, Italy

Outcomes

Primary Outcomes

Length of ICU stay

Time frame: Day 1 up to day 28

Secondary Outcomes

Glycemic variability as expressed by standard deviation of the glycemia measurements

Time frame: Day 1 up to day 28

Data from ClinicalTrials.gov

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