Does Cold Provocation Increase Brown Adipose Tissue Volume?

University Hospital, Linkoeping28 enrolled

Overview

About 28 healthy subjects are randomized to 1 hour/day of coldprovocation or to the best of ability to avoid feeling cold, for 6 weeks. Basal metabolic rate and magnetic resonance (for determination of brown adipose tissue volume) imaging are performed before and after the study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Brown Adipose Tissue, Human

Interventions

cold armPROCEDURE

1 hour/day of cold provocation of such an extent that it is unpleasant but does not cause shivering

warm armPROCEDURE

To the best of ability avoid feeling cold during 6 weeks

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: healthy subjects - Exclusion Criteria: any significant disease, ot other conditions that interferes with magnetic resonance imaging \-

Locations (1)

Faculty of Health Science, Linköping

Linköping, Sweden

Outcomes

Primary Outcomes

Brown Adipose Tissue, Absolute Volume

Sub-clavicular brown adipose tissue volume by magnetic resonance imaging (liters)

Time frame: Baseline and 6 week

Data from ClinicalTrials.gov

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