Insulin Sensitivity of the Human CNS System: fMRI Study With Intranasal Insulin Application

University Hospital Tuebingen48 enrolled

Overview

The purpose of the study is to investigate whether insulin sensitivity and insulin resistance of the human brain is comparable in all insulin sensitive parts of the brain and whether correlates to other phenotypic information (i.e. whole body insulin sensitivity, BMI, age) of the study participants.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Obesity Diabetes

Interventions

Human InsulinDRUG

160 U of insulin

PlaceboDRUG

Insulin dilution medium without insulin

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Normal routine blood works * for women: negative pregnancy test * healthy Exclusion Criteria: * Type 2 diabetes * pregnancy * acute or chronic diseases * Pacemakers * Artificial heart valves * Metal prostheses * Implanted magnetic metal parts (screws, ...) * Metal fragments * Braces * insulin pumps * Tattoos * claustrophobia * reduced temperature sensation and / or increased sensitivity to warming of the body * Ear disease or an increased sensitivity to loud noises

Locations (1)

University of Tuebingen

Tübingen, Germany

Outcomes

Primary Outcomes

Insulin effect on regional brain activity assessed by fMRI

Time frame: Change from Baseline to 15 minutes and 60 minutes post spray application

Data from ClinicalTrials.gov

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