Study of Cartilage Relaxometry and Physical Activity in Osteoarthritis

University Hospital, Akershus

Overview

This study is the radiological component of an earlier registered trial under the title: Efficacy of Exercise on Physical Function and Cartilage Health in Patients With Knee Osteoarthritis. The main purpose in this component of the study is to evaluate the efficacy of aerobic exercise and strength training on the T2 and T1 rho relaxation times of the articular cartilage. It has been proven that exercise can improve function and reduce the need for analgesics in patients with osteoarthritis. With this study, we wish to investigate if different kinds of exercise can cause measurable improvements in T2 and T1 rho relaxation times of the articular cartilage, and also if this improvements are transient or permanent.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Conditions

Osteoarthritis

Interventions

Strength TrainingOTHER

Aerobic ExerciseOTHER

Eligibility

Sex: ALLMin age: 45 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Women and men aged 45-65 years * Clinical knee OA according to the American College of Rheumatology Clinical Criteria 17 * Kellgren and Lawrence radiographic OA grade 2 and 3 (mild to moderate radiographic OA) Exclusion Criteria: * Severe knee OA according to the Kellgren and Lawrence classification (grade 4) * Other known major musculoskeletal impairments in the lower extremities or the back or prostheses in any joint of the lower extremities * Known coronary heart diseases or cancer * Body mass index \> 35 * Scheduled for surgery in any joint * Known mental or psychologic diseases * Known drug abuse * Persons who already perform sports related moderate physical activity more than two times a week * Contraindications for magnetic resonance imaging (specific point list at Diagnostic Imaging Division, Akershus University Hospital) * Not speaking Norwegian

Locations (1)

Akershus University Hospital

Lorenskog, Norway

Outcomes

Primary Outcomes

Qualitative Cartilage Morphology Assessment

Indirect cartilage morphology will by assessed by X-ray Direct cartilage morphology will be assessed by MRI morphometry The biochemical composition of the cartilage will be assessed by relaxometry (T2 and T1 rho relaxation times)

Time frame: One year

Secondary Outcomes

Semiquantitative Cartilage Assessment

Using semiquantitative techniques, the clinical manifestations of osteoarthritis assessed by MRI such as: cartilage lesions and bone marrow lesions will be assessed and quantified by MRI.

Time frame: One year

Data from ClinicalTrials.gov

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