To confirm the efficacy and safety of XELOX with capecitabine maintenance in treatment of elderly advanced gastric cancer (AGC) by comparing it with that of XELOX regimen.
To investigate whether XELOX with capecitabine maintenance treatment as 1st line treatment in the elderly advanced gastric cancer is as effective and safe as XELOX regimen.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
40
Oxaliplatin 100mg/m2 d1 Intravenous infusion every 3 weeks
capecitabine 850mg/m2 bid, d1-14, every 3 weeks
The tumor hospital of Harbin medical university
Harbin, Heilongjiang, China
RECRUITINGProgression Free Survival (PFS)
Time frame: From date of randomization until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 12 months
overall survival (OS)
Time frame: from the date of randomization until death from any cause or up to 1 year
Response Rate (RR)
Time frame: evaluate every 6 weeks after the date of randomization until diease progress or up to 12 weeks
adverse events (AE)
Time frame: from date of randomization to 28 days after the last chemo dosage
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