Atherosclerosis progressively occurs with increasing age in the general population. So far most dietary intervention studies with flavanols were performed over short time frames and in small groups of young healthy and older patients with manifest cardiovascular disease, respectively. Vascular health is defined as absence of vascular disease and the presence of optimal parameters that determine the development and progression of arteriosclerosis (endothelial function, blood pressure, plasma lipids, and glucose). It is not clear whether flavanols can improve parameters of vascular health, most importantly endothelial function, when given repetitively to healthy middle aged and which factors affect the efficacy of flavanol interventions.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
100
Division of Cardiology, Pulmonology and Vascular Medicine
Düsseldorf, North Rhine-Westphalia, Germany
Endothelial function
Time frame: Time points: day 0 [baseline], and day 30 each 0 and 2h.
Blood pressure
Time frame: Time points: day 0 [baseline], and day 30 each 0 and 2h.
Glucose
Time frame: Time points: day 0 [baseline], and day 30 each 0 and 2h.
Plasma lipids
Time frame: Time points: day 0 [baseline], and day 30 each 0 and 2h.
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