Planned Conversion From TAC to SRL-based Regimen in de Novo Kidney Transplant Recipients

Inclusion Criteria: * patients older than 18 years, * recipients of first kidney transplant from brain dead deceased or living related non-HLA identical donors not older than 65 years, * patients had to receive an ABO compatible organ with a CDC negative crossmatch and a peak panel reactive antibody lower that 30%, * all patients agreed to use contraceptive methods during the study and up to 3 months after study drug discontinuation. Exclusion Criteria: * patients with chronic kidney diseases due to focal and segmental glomerulosclerosis and membranoproliferative glomerulonephritis, * patients with active infection or positive for hepatitis B or C or human immunodeficiency viruses, * patients with previous history of malignancy, * patients with significant hematological or metabolic laboratorial abnormalities.