Skeletal Muscles, Myokines and Glucose Metabolism MYOGLU

Inclusion Criteria: * Male * Age 40-65 years * Nordic ethnicity * Non-smoker 1. Either (participants with impaired glucose metabolism): Body Mass Index (BMI) 27-32 kg/m2 and abnormal glucose metabolism, defined as: i. impaired fasting glucose (FPG ≥ 5.6 mmol/L) ii. impaired glucose tolerance (2 h PG ≥7.8 mmol/L) iii. type 2 diabetes (no medication, HbA1c ≤7.5%) 2. Or (controls): BMI 19-25 kg/m2 and normal glucose metabolism and no first degree relatives with type 2 diabetes. Exclusion Criteria: 1. Subjects having type 1 diabetes or medically treated type 2 diabetes. 2. Systolic blood pressure ≥ 160 mmHg or diastolic blood pressure ≥ 90 mmHg at screening 3. Significant hematological or renal disease or chronic renal impairment, GFR\< 50 ml/min. 4. Significant liver disease or ALAT \>3x UNL. 5. Chronic inflammatory disease in active phase or long-term use of corticosteroids last 3 months. 6. Use of anti-diabetic agents, lipid lowering drugs, antihypertensive medication, ASA or any other drug not deemed suitable by the study physician. 7. Mental condition (psychiatric or organic cerebral disease), drug or alcohol abuse rendering the subject unable to understand the nature, scope and possible consequences of the study. 8. BMI outside inclusion criteria. 9. Smoker 10. Any medical or other condition that in the judgment of the investigator would jeopardize the subject's safety or evaluation of the intervention for efficacy and safety 11. Exercising regularly (\>1 times pr week)