Magnesium Sulphate and Rocuronium in Patients Over 60

Pedro Rotava64 enrolled

Overview

The purpose of this study is to evaluate the effects of MgSO4 administration on the pharmacodynamics of rocuronium in patients with 60 or more years of age.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

TRIPLE

Enrollment

Conditions

Head and Neck Cancer

Interventions

Magnesium SulfateDRUG

MgSO4 30 mg/kg in 0.9% physiological saline (total volume 100 ml) intravenously, for 10 min, and then continuous intravenous infusion of MgSO4 at a rate of 1 g/h during the surgical procedure until the maximum of 3 h

PlaceboDRUG

100 ml of 0.9% physiological saline, for 10 min, and then continuous intravenous infusion of saline at a rate of 33 ml/h during the surgical procedure until the maximum of 3 h

Eligibility

Sex: ALLMin age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 60 years or older * ASA physical status I-III * Scheduled for elective oncologic head and neck surgery Exclusion Criteria: * Severe renal insufficiency (calculated creatinine clearance \< 30 ml/min) * Pre-operatory serum magnesium values \> 2.5 mEq/l * Patients receiving medications known to affect neuromuscular function (furosemide, aminoglycoside, anticonvulsivants, calcio channel blocker, litium, azatioprine, cyclofosfamide)

Locations (1)

Instituto Nacional de Câncer

Rio de Janeiro, Brazil